Sjors Scheres, Michel Goedert on Spooned by a Fold: MK-6240 Nestles Within Tau Protofilament
COMMENT This preprint by Kunach et al. describes a beautiful 2.1 Å resolution cryo-EM structure of PHFs from the frontal cortex of an individual with sporadic Alzheimer’s disease in complex with the PET ligand MK-6240. It represents the fourth cryo-EM structure o